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Remote Therapeutic Monitoring to Support Adoption of Bispecific Antibodies Therapy in Community Practices

Featured in: Journal of Clinical Pathways

Bispecific antibodies (BsAbs) are reshaping oncology treatment, but their complex toxicity profiles present unique barriers to outpatient adoption—particularly in community practices.

A new review in the Journal of Clinical Pathways, featuring authors from Canopy, outlines how Remote Therapeutic Monitoring (RTM) using electronic patient-reported outcomes (ePROs) can support the adoption of BsAbs in the outpatient setting by enabling earlier detection of symptoms, standardizing toxicity management, and reducing operational toxicity for clinical teams.

The manuscript reviews real-world findings on RTM use with BsAbs, including data from Canopy’s RTM platform, first presented at the 2024 American Society of Hematology (ASH) Meeting:

RTM identifies BsAb-related symptoms up to three weeks earlier than traditional phone-based follow-up.¹

Nearly all symptoms were reported more frequently through RTM compared to phone, including key toxicities¹

These studies build on Canopy’s broader RTM research, which have demonstrated:

45% improvement in treatment persistence at three months²

22% reduction in ER visits/hospitalizations per 100 patient months³

88% patient engagement sustained at six months⁴

Read the full review in the Journal of Clinical Pathways.

References

1. Derman, B. A., Essell, J. H., Kolodziej, M. A., Kwiatkowsky, L., Calkins, G., Parrinello, C. M., & Ascha, M. S. (2024, December 9). Electronic patient-reported outcome (ePRO) symptom monitoring for relapsed/refractory multiple myeloma in community settings, focusing on bispecific antibody therapy. American Society of Hematology Annual Meeting

2. Parrinello, C., Calkins, G., Kwiatkowsky, L., Schaefer, E. S., Beck, J. T., Ellis, A. R., Blau, S., Telivala, B. P., & Kolodziej, M. A. (2022). Time on treatment is prolonged in patients utilizing an ePRO based digital symptom monitoring platform in the community setting. Journal of Clinical Oncology, 40(16_suppl), 1528. DOI: 10.1200/JCO.2022.40.16_suppl.1528


3. Kolodziej, M. A., Kwiatkowsky, L., Parrinello, C., Thurow, T., Schaefer, E. S., Beck, J. T., Cherny, N., & Blau, S. (2022). ePRO-based digital symptom monitoring in a community oncology practice to reduce emergency room and inpatient utilization. Journal of Clinical Oncology, 40(16_suppl), 1508


4. Cherny, N. I., Parrinello, C. M., Kwiatkowsky, L., Hunnicutt, J., Beck, T., Schaefer, E., Thurow, T., & Kolodziej, M. (2022). Feasibility of Large-Scale Implementation of an Electronic Patient- Reported Outcome Remote Monitoring System for Patients on Active Treatment at a Community Cancer Center. JCO Oncology Practice, 18(12), e1918-e1926. DOI: 10.1200/OP.22.00180